Advantages

The imperfect correlation between the composition and abundance of mRNA and protein in a cell often interferes with our ability to readily make clear connections between human genes and diseases. Ribonomics, Inc. deciphers the organization of mRNAs and the RBPs that bridge the genome to the proteome, with the goal of discovering the molecular connections underlying a cellular and/or disease process. Ribonomics, Inc. expects this information to enhance target discovery and prioritization, target validation, drug screening and toxicogenomic strategies.

Upstream Pipeline Applications: Targets
Ribonomics provides a significant complement to existing expression technologies.
Our competitors use computational algorithms to predict relationships among genes and proteins and their involvement in disease states based on gene and protein expression data. Rather than trying to reverse engineer biological pathways and networks using computational tools, scientists at Ribonomics, Inc. directly illuminate the cell’s own system for coordination of gene expression. Using its proprietary methodology, the Company applies a "biological filter" and transforms basic transcriptomic and proteomic expression information into true pathways knowledge. This unique approach enables the Company and its partners to gain a clearer understanding of the molecular mechanisms of a disease, and therefore, to prioritize the best targets for therapeutic intervention. No competing technology accomplishes this as efficiently and effectively as the Ribonomics technology.

Downstream Pipeline Applications: Drugs
This technology also has downstream applications in the chemistry bottleneck for providing new insights into drug toxicity pathways and mechanisms of action. RNP Clusters are also a rich source of biomarkers for detecting disease presence/progression and monitoring drug efficacy during clinical trials. Again, by tapping into the cell's own organizing scheme, Ribonomics provides groundbreaking insights into cellular pathways and biological processes. More importantly, mRNAs that localize in common RNP clusters encode proteins that are involved in common physiological pathways. Thus, in a completely novel manner, Ribonomics, Inc. enables the discovery of members of functional pathways, connections among pathways, and association of those pathways to disease.